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A growing body of evidence suggests that during certain stressful times, the body may require more glutamine than it can produce. Under these circumstances, glutamine may be considered a \"conditionally essential\" amino acid. Glutamine is involved in maintaining a positive nitrogen balance (an anabolic state) and also aids rapidly growing cells (immune system lymphocytes and intestinal cell enterocytes). 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It's bursting onto the fitness scene in a big way, helping people of all ages break through the boundaries of personal health and fitness. L-citrulline is active in both the Krebs cycle and the Urea cycle of metabolism, which means it promotes energy production to fuel activity while simultaneously helping to rid the body of metabolic waste products, helping to promote muscle recovery after exercise\u003csup\u003e1\u003c\/sup\u003e. The addition of malate, a form of malic acid, further bolsters the bioavailability of L-citrulline.\u003c\/p\u003e\u003cp\u003eL-citrulline is an amino acid precursor to—and more efficiently absorbed by the body than—arginine which in turn produces nitric oxide. Nitric oxide works to deliver oxygen and other nutrients throughout the body to feed muscles and tissues. This is especially beneficial during high-intensity exercise, and may also help maintain blood pressure already within the normal range\u003csup\u003e2\u003c\/sup\u003e, support men’s sexual health\u003csup\u003e2\u003c\/sup\u003e, and encourage active aging by promoting cardiometabolic health in older adults\u003csup\u003e3\u003c\/sup\u003e.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e\u003cspan style=\"font-size: 10pt;\"\u003eSources\u003c\/span\u003e\u003c\/p\u003e\u003col\u003e\n\u003cli style=\"font-size: 10pt;\"\u003e\u003cspan style=\"font-size: 10pt;\"\u003eFarney, T, et al., Journal of Strength and Conditioning Research 33(9):p 2464-2470, September 2019. | Read more.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-size: 10pt;\"\u003e\u003cspan style=\"font-size: 10pt;\"\u003eNeri, L. Examine.com, accessed 10 June 2025\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-size: 10pt;\"\u003e\u003cspan style=\"font-size: 10pt;\"\u003eAllerton TD, et al. 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L-Citrulline Malate is active in both the Krebs cycle and the urea cycle of metabolism, which means it promotes energy production while simultaneously helping to rid the body of fatigue-causing metabolic waste products.\u003c\/p\u003e\u003cp\u003eL-Citrulline is a unique amino acid first isolated from watermelon and produced in the body from the amino acids ornithine and arginine. It's a key player in the urea cycle, which is the process responsible for eliminating the metabolic by-products of protein metabolism. These by-products, primarily ammonia and lactic acid, contribute to muscle fatigue. By helping to efficiently remove them, L-citrulline helps fend off fatigue for greater comfort and endurance. 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